The Syrian government has carried out a state policy of extermination against thousands of detainees, UN human rights investigators say.
They accuse President Bashar al-Assad's regime of crimes against humanity, in a report for the UN Human Rights Council.
The study says both loyalist and anti-government forces have committed possible war crimes.
Many detainees were tortured, some were beaten to death, and others died from lack of food, water, or medical care.
The findings come from interviews with hundreds of witnesses and cover the period since the start of anti-government protests in March 2011.
The report says thousands of detainees have been killed while in the custody of warring parties during that time.
Syria torture photos 'authentic' - rights group
Investigators suspect tens of thousands of people are detained by Syria's government at any one time.
Their report describes the situation of detainees as an "urgent and large-scale crisis of human rights protection".
Survivors' accounts "paint a terrifying picture of the magnitude of the violations taking place," it said.
The civil war in Syria has claimed an estimated 250,000 lives so far.
About 4.6 million people have fled Syria, while another 13.5 million are said to be in need of humanitarian assistance inside the country.
Extract from February 2016 report for UN Human Rights Council
Main detention facilities controlled by the General Intelligence Directorate include Interior Security branch 251 and Investigations branch 285 located in Kafr Soussa, west of central Damascus.
Former detainees described inhuman conditions of detention resulting in frequent custodial deaths.
Officers were observed giving orders to subordinates on methods of torture to be used on detainees.
Corpses were transported by other prisoners through the corridors, sometimes to be kept in the toilets, before being removed from the branch.
Evidence obtained indicates that the superiors of the facilities were regularly informed of the deaths of detainees under their control. Prisoners were transferred to military hospitals before they were buried in mass graves.
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